ABSTRACT
PURPOSE: The short- and long-term andrological effects of coronavirus disease 2019 (COVID-19) have not been clarified. Our aim is to evaluate the available evidence regarding possible andrological consequences of COVID-19 either on seminal or hormonal parameters. The safety of the COVID-19 vaccines in terms of sperm quality was also investigated. METHODS: All prospective and retrospective observational studies reporting information on severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) mRNA semen and male genitalia tract detection (n = 19), as well as those reporting data on semen analysis (n = 5) and hormonal parameters (n = 11) in infected/recovered patients without any arbitrary restriction were included. RESULTS: Out of 204 retrieved articles, 35 were considered, including 2092 patients and 1138 controls with a mean age of 44.1 ± 12.6 years, and mean follow-up 24.3 ± 18.9 days. SARS-CoV-2 mRNA can be localized in male genitalia tracts during the acute phase of the disease. COVID-19 can result in short-term impaired sperm and T production. Available data cannot clarify long-term andrological effects. Low T observed in the acute phase of the disease is associated with an increased risk of being admitted to the Intensive Care Unit or death. The two available studies showed that the use of mRNA COVID-19 vaccines does not affect sperm quality. CONCLUSIONS: The results of our analysis clearly suggest that each patient recovering from COVID-19 should be monitored to rule out sperm and T abnormalities. The specific contribution of reduced T levels during the acute phase of the infection needs to be better clarified.
Subject(s)
COVID-19 , Male , Humans , Adult , Middle Aged , SARS-CoV-2 , COVID-19 Vaccines , Prospective Studies , Retrospective Studies , Semen , RNA, MessengerABSTRACT
Algorithmic personalization is difficult to approach because it entails studying many different user experiences, with a lot of variables outside of our control. Two common biases are frequent in experiments: relying on corporate service API and using synthetic profiles with small regards of regional and individualized profiling and personalization. In this work, we present the result of the first crowdsourced data collections of YouTube’s recommended videos via YouTube Tracking Exposed (YTTREX). Our tool collects evidence of algorithmic personalization via an HTML parser, anonymizing the users. In our experiment we used a BBC video about COVID-19, taking into account 5 regional BBC channels in 5 different languages and we saved the recommended videos that were shown during each session. Each user watched the first five second of the videos, while the extension captured the recommended videos. We took into account the top20 recommended videos for each completed session, looking for evidence of algorithmic personalization. Our results showed that the vast majority of videos were recommended only once in our experiment. Moreover, we collected evidence that there is a significant difference between the videos we could retrieve using the official API and what we collected with our extension. These findings show that filter bubbles exist and that they need to be investigated with a crowdsourced approach. © 2021, Springer Nature Switzerland AG.
ABSTRACT
PURPOSE: The recent pandemic of severe acute respiratory syndrome (SARS) due to coronavirus (CoV) 2 (SARS-CoV-2) has raised several concerns in reproductive medicine. The aim of this review is to summarize available evidence providing an official position statement of the Italian Society of Andrology and Sexual Medicine (SIAMS) METHODS: A comprehensive Pubmed, Web of Science, Embase, Medline and Cochrane library search was performed. Due to the limited evidence and the lack of studies, it was not possible to formulate recommendations according to the Oxford 2011 Levels of Evidence criteria. RESULTS: Several molecular characteristics of the SARS-CoV-2 can justify the presence of virus within the testis and possible alterations of spermatogenesis and endocrine function. Orchitis has been reported as a possible complication of SARS-CoV infection, but similar findings have not been reported for SARS-CoV-2. Alternatively, the orchitis could be the result of a vasculitis as COVID-19 has been associated with abnormalities in coagulation and the segmental vascularization of the testis could account for an orchitis-like syndrome. Finally, available data do not support the presence of SARS-CoV-2 in plasma seminal fluid of infected subjects. CONCLUSION: Data derived from other SARS-CoV infections suggest that in patients recovered from COVID-19, especially for those in reproductive age, andrological consultation and evaluation of gonadal function including semen analysis should be suggested. Studies in larger cohorts of currently infected subjects are warranted to confirm (or exclude) the presence of risks for male gametes that are destined either for cryopreservation in liquid nitrogen or for assisted reproduction techniques.